Directors’ interests
There were no contracts of significance subsisting during or at the end of the year in which a Director of the company is or was materially interested.

Interests in shares
The Directors’ and their families’ beneficial interests in the share capital of the company are shown below:

	31 Dec 2001 Ordinary 5p shares		As at 31 Dec 2000 or at date of appointment Ordinary 5p shares
G W Battersby	25,000		-
D H Brydon	2,585		2,585
W M Castell	243,570		177,769
J H Johansen	11,610		11,610
G F B Kerr	10,000		10,000
R D Lapthorne	105,170		105,170
J Fr Odfjell	53,150		53,150
J M Padfield	3,564		3,564
J Patterson	2,923		-
K Peters	-		-
J F Rejeange	-		-
E Thorsby	17,800		10,800
	475,372		374,648

Details of interests in conditional awards under the LTIP are detailed on page 52 of this Report. Each Director is deemed to be interested in all of the shares held by the Amersham ESOP Trust, which at 31 December 2001 amounted to 551,934 ordinary 5p shares (1 January 2001 – 639,033 ordinary 5p shares). Each Executive Director is deemed to be interested in all of the shares held by Amersham Trustees Limited (the trustee of a UK Inland Revenue tax approved QUEST) which amounted to 1,607,294 ordinary 5p shares at 31 December 2001 (1 January 2001 – 103,175 ordinary 5p shares).

There has been no change since the year end in the interest of Directors in the company’s shares.

Interests in share options
The interests of the Directors in Amersham plc share options held under the Executive Share Option Scheme (ESOS) and the Sharesave scheme (SAYE) are set out below. These options are exercisable from November 1996 to September 2011 and are held under the company’s plans referred to in note 25 to the accounts. No options lapsed during the year.

Option interests'

		At 31 Dec 2000 or date of appointment				Granted during the year				Exercised during the year						At 31 Dec 2001
		No.of ordinary 5p shares		Weighted average subscription price		No. of ordinary 5p shares		Weighted average subscription price		No. of ordinary 5p shares		Weighted average subscription price		Market price on date of exercise		No. of ordinary 5p shares		Weighted average subscription price
W M Castell
ESOS		759,139		£3.98		-		-		218,742		£3.91682		£5.44		303,922		£5.69
		-		-		-		-		236,475		£1.87427		£5.57		-		-
ESOS 2001		-		-		178,572		£5.60		-		-		-		178,572		£5.60
SAYE		8,004		£2.13		-		-		5,325		£1.54158		£6.055		2,679		£3.30
G W Battersby
ESOS		128,618		£6.22		-		-		-		-		-		128,618		£6.22
ESOS 2001		-		-		85,716		£5.60		-		-		-		85,716		£5.60
SAYE		3,402		£4.96		-		-		-		-		-		3,402		£4.96
G F B Kerr
ESOS		282,813		£4.45		-		-		-		-		-		282,813		£4.45
ESOS 2001		-		-		100,000		£5.60		-		-		-		100,000		£5.60
SAYE		-		-		-		-		-		-		-		-		-
J M Padfield
ESOS 2001		407,447		£4.57		-		-		-		-		-		407,447		£4.57
ESOS 2001		-		-		121,432		£5.60		-		-		-		121,432		£5.60
SAYE		5,568		£3.30		-		-		-		-		-		5,568		£3.30

No other Directors have been granted options over the shares of the company or any other group companies.

The company’s register of Directors’ interests, which is open for inspection, contains full details of Directors’ share interests and options to subscribe for shares.

London share prices
The market price of the company’s ordinary 5p shares at the end of the financial period was 664.5p. The range of market prices during the year was as follows:

	1 Jan 2001 to 31 Dec 2001
	Low		High
Ordinary 5p shares	428.5p		673.5p

On behalf of the Board
R D Lapthorne
Chairman, Remuneration Committee
25 February 2002

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